000 - Document - Document And Entity Information link:calculationLink link:definitionLink link:presentationLink 001 - Statement - Unaudited Condensed Consolidated Balance Sheets link:calculationLink link:definitionLink link:presentationLink 002 - Statement - Unaudited Condensed Consolidated Balance Sheets (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 003 - Statement - Unaudited Condensed Consolidated Statements of Operations link:calculationLink link:definitionLink link:presentationLink 004 - Statement - Unaudited Condensed Consolidated Statements of Changes in Stockholders' Equity link:calculationLink link:definitionLink link:presentationLink 005 - Statement - Unaudited Condensed Consolidated Statements of Cash Flows link:calculationLink link:definitionLink link:presentationLink 006 - Disclosure - Note A - Description of Business and Basis of Presentation link:calculationLink link:definitionLink link:presentationLink 007 - Disclosure - Note B - Summary of Significant Accounting Policies link:calculationLink link:definitionLink link:presentationLink 008 - Disclosure - Note C - Debt Obligations link:calculationLink link:definitionLink link:presentationLink 009 - Disclosure - Note D - Commitments and Contingencies link:calculationLink link:definitionLink link:presentationLink 010 - Disclosure - Note E - Preferred Stock and Warrants link:calculationLink link:definitionLink link:presentationLink 011 - Disclosure - Note F - Common Stock and Warrants link:calculationLink link:definitionLink link:presentationLink 012 - Disclosure - Note G - Stock-based Compensation link:calculationLink link:definitionLink link:presentationLink 013 - Disclosure - Note H - Fair Value of Financial Instruments link:calculationLink link:definitionLink link:presentationLink 014 - Disclosure - Note I - Net Loss Per Share link:calculationLink link:definitionLink link:presentationLink 015 - Disclosure - Note J - Leases link:calculationLink link:definitionLink link:presentationLink 016 - Disclosure - Significant Accounting Policies (Policies) link:calculationLink link:definitionLink link:presentationLink 017 - Disclosure - Note A - Description of Business and Basis of Presentation (Tables) link:calculationLink link:definitionLink link:presentationLink 018 - Disclosure - Note F - Common Stock and Warrants (Tables) link:calculationLink link:definitionLink link:presentationLink 019 - Disclosure - Note G - Stock-based Compensation (Tables) link:calculationLink link:definitionLink link:presentationLink 020 - Disclosure - Note H - Fair Value of Financial Instruments (Tables) link:calculationLink link:definitionLink link:presentationLink 021 - Disclosure - Note I - Net Loss Per Share (Tables) link:calculationLink link:definitionLink link:presentationLink 022 - Disclosure - Note J - Leases (Tables) link:calculationLink link:definitionLink link:presentationLink 023 - Disclosure - Note A - Description of Business and Basis of Presentation (Details Textual) link:calculationLink link:definitionLink link:presentationLink 024 - Disclosure - Note A - Description of Business and Basis of Presentation - Consideration Paid and Purchase Price Allocation for the Acquisition of Arimoclomol (Details) link:calculationLink link:definitionLink link:presentationLink 025 - Disclosure - Note B - Summary of Significant Accounting Policies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 026 - Disclosure - Note C - Debt Obligations (Details Textual) link:calculationLink link:definitionLink link:presentationLink 027 - Disclosure - Note D - Commitments and Contingencies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 028 - Disclosure - Note E - Preferred Stock and Warrants (Details Textual) link:calculationLink link:definitionLink link:presentationLink 029 - Disclosure - Note F - Common Stock and Warrants (Details Textual) link:calculationLink link:definitionLink link:presentationLink 030 - Disclosure - Note F - Common Stock and Warrants - Reserved Authorized Shares of Common Stock for Future Issuance (Details) link:calculationLink link:definitionLink link:presentationLink 031 - Disclosure - Note F - Common Stock and Warrants - Common Stock Activity (Details) link:calculationLink link:definitionLink link:presentationLink 032 - Disclosure - Note G - Stock-based Compensation (Details Textual) link:calculationLink link:definitionLink link:presentationLink 033 - Disclosure - Note G - Stock-based Compensation - Stock-based Compensation Expense (Details) link:calculationLink link:definitionLink link:presentationLink 034 - Disclosure - Note H - Fair Value of Financial Instruments (Details Textual) link:calculationLink link:definitionLink link:presentationLink 035 - Disclosure - Note H - Fair Value of Financial Instruments - Assets and Liabilities Measured at Fair Value on Recurring Basis (Details) link:calculationLink link:definitionLink link:presentationLink 036 - Disclosure - Note H - Fair Value of Financial Instruments - Reconciliation of Beginning and Ending Balances for Derivative and Warrant Liability Measured at Fair Value on Recurring Basis (Details) link:calculationLink link:definitionLink link:presentationLink 037 - Disclosure - Note I - Net Income (Loss) Per Share - Anti-dilutive Securities (Details) link:calculationLink link:definitionLink link:presentationLink 038 - Disclosure - Note I - Net Income (Loss) Per Share - Earnings Per Share (Details) link:calculationLink link:definitionLink link:presentationLink 039 - Disclosure - Note J - Leases (Details Textual) link:calculationLink link:definitionLink link:presentationLink 040 - Disclosure - Note J - Leases - Lease Cost (Details) link:calculationLink link:definitionLink link:presentationLink 041 - Disclosure - Note J - Leases - Supplement Cash Flow Information Related to Leases (Details) link:calculationLink link:definitionLink link:presentationLink 042 - Disclosure - Note J - Leases - Supplement Balance Sheet Information Related to Lease (Details) link:calculationLink link:definitionLink link:presentationLink 043 - Disclosure - Note J - Leases - Maturities of lease Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink