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  <xsd:element id="zvra_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityCumulativeEffectAdjustment" name="FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityCumulativeEffectAdjustment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
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  <xsd:element id="zvra_SharesAndWarrantsIssuedPricePerShare" name="SharesAndWarrantsIssuedPricePerShare" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" xbrli:periodType="instant"/>
  <xsd:element id="zvra_StockIssuableDuringThePeriod" name="StockIssuableDuringThePeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="zvra_UnderwritingAgreementAndOverallotmentOptionMember" name="UnderwritingAgreementAndOverallotmentOptionMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="zvra_XomaLicenseAgreementMember" name="XomaLicenseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_ZVRAAdrianWQuartelMember" name="ZVRAAdrianWQuartelMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_ZVRAJoshuaSchaferMember" name="ZVRAJoshuaSchaferMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_ZVRANeilFMcFarlaneMember" name="ZVRANeilFMcFarlaneMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_ZVRARLaDuaneCliftonMember" name="ZVRARLaDuaneCliftonMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_ZVRARahsaanThompsonMember" name="ZVRARahsaanThompsonMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_ZVRATimothyJSangiovanniMember" name="ZVRATimothyJSangiovanniMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="zvra_statement-statement-note-e-debt-obligations-aggregate-principal-amount-details" name="statement-statement-note-e-debt-obligations-aggregate-principal-amount-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-e-debt-obligations-future-minimum-principal-payments-details" name="statement-statement-note-e-debt-obligations-future-minimum-principal-payments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="zvra_statement-statement-note-f-revenue-net-schedule-of-accounts-and-other-receivables-details" name="statement-statement-note-f-revenue-net-schedule-of-accounts-and-other-receivables-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-f-revenue-net-tables" name="statement-statement-note-f-revenue-net-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-g-stock-and-warrants-common-stock-activity-details" name="statement-statement-note-g-stock-and-warrants-common-stock-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-g-stock-and-warrants-reserved-authorized-shares-of-common-stock-for-future-issuance-details" name="statement-statement-note-g-stock-and-warrants-reserved-authorized-shares-of-common-stock-for-future-issuance-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-g-stock-and-warrants-tables" name="statement-statement-note-g-stock-and-warrants-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-h-stockbased-compensation-stockbased-compensation-expense-details" name="statement-statement-note-h-stockbased-compensation-stockbased-compensation-expense-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="zvra_statement-statement-note-i-fair-value-of-financial-instruments-assets-and-liabilities-measured-at-fair-value-on-recurring-basis-details" name="statement-statement-note-i-fair-value-of-financial-instruments-assets-and-liabilities-measured-at-fair-value-on-recurring-basis-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="zvra_statement-statement-note-i-fair-value-of-financial-instruments-reconciliation-of-beginning-and-ending-balances-for-derivative-and-warrant-liability-measured-at-fair-value-on-recurring-basis-details" name="statement-statement-note-i-fair-value-of-financial-instruments-reconciliation-of-beginning-and-ending-balances-for-derivative-and-warrant-liability-measured-at-fair-value-on-recurring-basis-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="zvra_statement-statement-note-j-net-loss-per-share-antidilutive-securities-details" name="statement-statement-note-j-net-loss-per-share-antidilutive-securities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-j-net-loss-per-share-earnings-per-share-details" name="statement-statement-note-j-net-loss-per-share-earnings-per-share-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="zvra_statement-statement-note-k-leases-lease-cost-details" name="statement-statement-note-k-leases-lease-cost-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-k-leases-maturities-of-lease-liabilities-details" name="statement-statement-note-k-leases-maturities-of-lease-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-k-leases-supplement-balance-sheet-information-related-to-lease-details" name="statement-statement-note-k-leases-supplement-balance-sheet-information-related-to-lease-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-k-leases-supplement-balance-sheet-information-related-to-lease-details-parentheticals" name="statement-statement-note-k-leases-supplement-balance-sheet-information-related-to-lease-details-parentheticals" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-k-leases-supplement-cash-flow-information-related-to-leases-details" name="statement-statement-note-k-leases-supplement-cash-flow-information-related-to-leases-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-k-leases-tables" name="statement-statement-note-k-leases-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-l-goodwill-intangible-assets-amortization-of-intangible-assets-details" name="statement-statement-note-l-goodwill-intangible-assets-amortization-of-intangible-assets-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-l-goodwill-intangible-assets-tables" name="statement-statement-note-l-goodwill-intangible-assets-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-significant-accounting-policies-policies" name="statement-statement-significant-accounting-policies-policies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
</xsd:schema>
