000 - Document - Document And Entity Information link:calculationLink link:definitionLink link:presentationLink 001 - Statement - Balance Sheets link:calculationLink link:definitionLink link:presentationLink 002 - Statement - Balance Sheets (Parentheticals) link:calculationLink link:definitionLink link:presentationLink 003 - Statement - Statements of Operations link:calculationLink link:definitionLink link:presentationLink 004 - Statement - Consolidated Statements of Comprehensive Income (Loss) link:calculationLink link:definitionLink link:presentationLink 005 - Statement - Statements of Changes in Stockholders' Equity (Deficit) link:calculationLink link:definitionLink link:presentationLink 006 - Statement - Statements of Cash Flows link:calculationLink link:definitionLink link:presentationLink 007 - Disclosure - Note A - Description of Business, Basis of Presentation, and Significant Transactions link:calculationLink link:definitionLink link:presentationLink 008 - Disclosure - Note B - Summary of Significant Accounting Policies link:calculationLink link:definitionLink link:presentationLink 009 - Disclosure - Note C - Accounts and Other Receivables link:calculationLink link:definitionLink link:presentationLink 010 - Disclosure - Note D - Prepaid Expenses and Other Current Assets link:calculationLink link:definitionLink link:presentationLink 011 - Disclosure - Note E - Property and Equipment link:calculationLink link:definitionLink link:presentationLink 012 - Disclosure - Note F - Accounts Payable and Accrued Expenses link:calculationLink link:definitionLink link:presentationLink 013 - Disclosure - Note G - Debt Obligations link:calculationLink link:definitionLink link:presentationLink 014 - Disclosure - Note H - Commitments and Contingencies link:calculationLink link:definitionLink link:presentationLink 015 - Disclosure - Note I - Preferred Stock and Warrants link:calculationLink link:definitionLink link:presentationLink 016 - Disclosure - Note J - Common Stock and Warrants link:calculationLink link:definitionLink link:presentationLink 017 - Disclosure - Note K - Stock-based Compensation link:calculationLink link:definitionLink link:presentationLink 018 - Disclosure - Note L - Fair Value of Financial Instruments link:calculationLink link:definitionLink link:presentationLink 019 - Disclosure - Note M - Income Taxes link:calculationLink link:definitionLink link:presentationLink 020 - Disclosure - Note N - Net Loss Per Share link:calculationLink link:definitionLink link:presentationLink 021 - Disclosure - Note O - Leases link:calculationLink link:definitionLink link:presentationLink 022 - Disclosure - Note P - Employee Benefit Plan link:calculationLink link:definitionLink link:presentationLink 023 - Disclosure - Note Q - Significant Events link:calculationLink link:definitionLink link:presentationLink 024 - Disclosure - Note R - Subsequent Events link:calculationLink link:definitionLink link:presentationLink 025 - Disclosure - Significant Accounting Policies (Policies) link:calculationLink link:definitionLink link:presentationLink 026 - Disclosure - Note A - Description of Business, Basis of Presentation, and Significant Transactions (Tables) link:calculationLink link:definitionLink link:presentationLink 027 - Disclosure - Note C - Accounts and Other Receivables (Tables) link:calculationLink link:definitionLink link:presentationLink 028 - Disclosure - Note D - Prepaid Expenses and Other Current Assets (Tables) link:calculationLink link:definitionLink link:presentationLink 029 - Disclosure - Note E - Property and Equipment (Tables) link:calculationLink link:definitionLink link:presentationLink 030 - Disclosure - Note F - Accounts Payable and Accrued Expenses (Tables) link:calculationLink link:definitionLink link:presentationLink 031 - Disclosure - Note J - Common Stock and Warrants (Tables) link:calculationLink link:definitionLink link:presentationLink 032 - Disclosure - Note K - Stock-based Compensation (Tables) link:calculationLink link:definitionLink link:presentationLink 033 - Disclosure - Note L - Fair Value of Financial Instruments (Tables) link:calculationLink link:definitionLink link:presentationLink 034 - Disclosure - Note M - Income Taxes (Tables) link:calculationLink link:definitionLink link:presentationLink 035 - Disclosure - Note N - Net Loss Per Share (Tables) link:calculationLink link:definitionLink link:presentationLink 036 - Disclosure - Note O - Leases (Tables) link:calculationLink link:definitionLink link:presentationLink 037 - Disclosure - Note A - Description of Business, Basis of Presentation, and Significant Transactions (Details Textual) link:calculationLink link:definitionLink link:presentationLink 038 - Disclosure - Note A - Description of Business, Basis of Presentation, and Significant Transactions - Consideration Paid and Purchase Price Allocation for the Acquisition of Arimoclomol (Details) link:calculationLink link:definitionLink link:presentationLink 039 - Disclosure - Note B - Summary of Significant Accounting Policies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 040 - Disclosure - Note C - Accounts and Other Receivables - Accounts and Other Receivables (Details) link:calculationLink link:definitionLink link:presentationLink 041 - Disclosure - Note D - Prepaid Expenses and Other Current Assets - Components of Prepaid Expenses and Other Current Assets (Details) link:calculationLink link:definitionLink link:presentationLink 042 - Disclosure - Note E - Property and Equipment (Details Textual) link:calculationLink link:definitionLink link:presentationLink 043 - Disclosure - Note E - Property and Equipment - Components of Property and Equipment (Details) link:calculationLink link:definitionLink link:presentationLink 044 - Disclosure - Note E - Property and Equipment - Estimated Useful Lives of Property and Equipment (Details) link:calculationLink link:definitionLink link:presentationLink 045 - Disclosure - Note F - Accounts Payable and Accrued Expenses - Accounts Payable and Accrued Expenses (Details) link:calculationLink link:definitionLink link:presentationLink 046 - Disclosure - Note G - Debt Obligations (Details Textual) link:calculationLink link:definitionLink link:presentationLink 047 - Disclosure - Note H - Commitments and Contingencies (Details Textual) link:calculationLink link:definitionLink link:presentationLink 048 - Disclosure - Note I - Preferred Stock and Warrants (Details Textual) link:calculationLink link:definitionLink link:presentationLink 049 - Disclosure - Note J - Common Stock and Warrants (Details Textual) link:calculationLink link:definitionLink link:presentationLink 050 - Disclosure - Note J - Common Stock and Warrants - Reserved Authorized Shares of Common Stock for Future Issuance (Details) link:calculationLink link:definitionLink link:presentationLink 051 - Disclosure - Note J - Common Stock and Warrants - Common Stock Activity (Details) link:calculationLink link:definitionLink link:presentationLink 052 - Disclosure - Note K - Stock-based Compensation (Details Textual) link:calculationLink link:definitionLink link:presentationLink 053 - Disclosure - Note K - Stock-based Compensation - Stock-based Compensation Expense (Details) link:calculationLink link:definitionLink link:presentationLink 054 - Disclosure - Note K - Stock-based Compensation - Black-Scholes Option-pricing Model (Details) link:calculationLink link:definitionLink link:presentationLink 055 - Disclosure - Note K - Stock-based Compensation - Schedule of Stock Option Activity (Details) link:calculationLink link:definitionLink link:presentationLink 056 - Disclosure - Note K - Stock-based Compensation - Information Regarding Currently Outstanding and Exercisable Options (Details) link:calculationLink link:definitionLink link:presentationLink 057 - Disclosure - Note K - Stock-based Compensation - Nonvested Stock Option Awards (Details) link:calculationLink link:definitionLink link:presentationLink 058 - Disclosure - Note L - Fair Value of Financial Instruments (Details Textual) link:calculationLink link:definitionLink link:presentationLink 059 - Disclosure - Note L - Fair Value of Financial Instruments - Assets and Liabilities Measured at Fair Value on Recurring Basis (Details) link:calculationLink link:definitionLink link:presentationLink 060 - Disclosure - Note L - Fair Value of Financial Instruments - Reconciliation of Beginning and Ending Balances for Derivative and Warrant Liability Measured at Fair Value on Recurring Basis (Details) link:calculationLink link:definitionLink link:presentationLink 061 - Disclosure - Note M - Income Taxes (Details Textual) link:calculationLink link:definitionLink link:presentationLink 062 - Disclosure - Note M - Income Taxes - Schedule of Reconciliation of Difference Between Benefit for Income Taxes and Income Taxes at Statutory U.S. Federal Income Tax Rate (Details) link:calculationLink link:definitionLink link:presentationLink 063 - Disclosure - Note M - Income Taxes - Components of Net Deferred Tax Assets and Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 064 - Disclosure - Note N - Net Loss Per Share - Anti-dilutive Securities (Details) link:calculationLink link:definitionLink link:presentationLink 065 - Disclosure - Note N - Net Loss Per Share - Earnings Per Share (Details) link:calculationLink link:definitionLink link:presentationLink 066 - Disclosure - Note O - Leases (Details Textual) link:calculationLink link:definitionLink link:presentationLink 067 - Disclosure - Note O - Leases - Lease Cost (Details) link:calculationLink link:definitionLink link:presentationLink 068 - Disclosure - Note O - Leases - Supplement Cash Flow Information Related to Leases (Details) link:calculationLink link:definitionLink link:presentationLink 069 - Disclosure - Note O - Leases - Supplement Balance Sheet Information Related to Lease (Details) link:calculationLink link:definitionLink link:presentationLink 070 - Disclosure - Note O - Leases - Maturities of lease Liabilities (Details) link:calculationLink link:definitionLink link:presentationLink 071 - Disclosure - Note P - Employee Benefit Plan (Details Textual) link:calculationLink link:definitionLink link:presentationLink 072 - Disclosure - Note Q - Significant Events (Details Textual) link:calculationLink link:definitionLink link:presentationLink