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  <xsd:element id="zvra_IncomeTaxExaminationNumberOfReturnsUnderExamination" name="IncomeTaxExaminationNumberOfReturnsUnderExamination" nillable="true" substitutionGroup="xbrli:item" type="xbrli:integerItemType" xbrli:periodType="instant"/>
  <xsd:element id="zvra_IncomeTaxExpenseBenefitNoncashAdjustment" name="IncomeTaxExpenseBenefitNoncashAdjustment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="zvra_IncreaseDecreaseInDiscountAndRebateLiabilities" name="IncreaseDecreaseInDiscountAndRebateLiabilities" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="zvra_IncreaseDecreaseInOperatingLeaseRightofuseAsset" name="IncreaseDecreaseInOperatingLeaseRightofuseAsset" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="zvra_IndirectOperatingCostsMember" name="IndirectOperatingCostsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="zvra_InterestAndOtherIncomeExpenseNet" name="InterestAndOtherIncomeExpenseNet" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="zvra_InventoryCurrentAndNoncurrentTotal" name="InventoryCurrentAndNoncurrentTotal" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="zvra_JMPAndRBCCMMember" name="JMPAndRBCCMMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
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  <xsd:element id="zvra_LesseeLeaseOptionToTerminateTerm" name="LesseeLeaseOptionToTerminateTerm" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element id="zvra_LesseeLeaseRemainingTermOfContract" name="LesseeLeaseRemainingTermOfContract" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_LicenseAgreementAndTerminationAgreementMember" name="LicenseAgreementAndTerminationAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="zvra_LineOfCreditFacilityMaximumBorrowingCapacityPercentageOfInvestments" name="LineOfCreditFacilityMaximumBorrowingCapacityPercentageOfInvestments" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="instant"/>
  <xsd:element abstract="true" id="zvra_LitigationRelatedToMergerMember" name="LitigationRelatedToMergerMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="zvra_LossOnSubleaseAndDisposalOfPropertyAndEquipment" name="LossOnSubleaseAndDisposalOfPropertyAndEquipment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
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  <xsd:element id="zvra_MaximumRoyaltyObligation" name="MaximumRoyaltyObligation" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
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  <xsd:element abstract="true" id="zvra_NantahalaNoteMember" name="NantahalaNoteMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="zvra_PossibleFutureIssuancesUnderEmployeeStockPurchasePlansMember" name="PossibleFutureIssuancesUnderEmployeeStockPurchasePlansMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
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  <xsd:element id="zvra_PropertyPlantAndEquipmentUsefulLifeTableTextBlock" name="PropertyPlantAndEquipmentUsefulLifeTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
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  <xsd:element id="zvra_RevenueRecognitionMilestoneMethodAdditionalRevenueToBeRecognized" name="RevenueRecognitionMilestoneMethodAdditionalRevenueToBeRecognized" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="instant"/>
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  <xsd:element id="zvra_ScheduleOfAuthorizedSharesOfCommonStockReservedForFutureIssuanceTableTextBlock" name="ScheduleOfAuthorizedSharesOfCommonStockReservedForFutureIssuanceTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
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  <xsd:element id="zvra_ScheduleOfLeasesCashFlowInformationTableTextBlock" name="ScheduleOfLeasesCashFlowInformationTableTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
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  <xsd:element id="zvra_SharebasedCompensationArrangementBySharebasedPaymentAwardNumberOfSharesReservedForIssuanceIncrementalPercentageOfCapitalStockOutstanding" name="SharebasedCompensationArrangementBySharebasedPaymentAwardNumberOfSharesReservedForIssuanceIncrementalPercentageOfCapitalStockOutstanding" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:percentItemType" xbrli:periodType="duration"/>
  <xsd:element id="zvra_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodIntrinsicValue" name="SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsForfeituresAndExpirationsInPeriodIntrinsicValue" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="debit" xbrli:periodType="duration"/>
  <xsd:element id="zvra_SharesAndWarrantsIssuedPricePerShare" name="SharesAndWarrantsIssuedPricePerShare" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:perShareItemType" xbrli:periodType="instant"/>
  <xsd:element id="zvra_StockIssuableDuringThePeriod" name="StockIssuableDuringThePeriod" nillable="true" substitutionGroup="xbrli:item" type="xbrli:sharesItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="zvra_SwkLoansAndMarathonNotesMember" name="SwkLoansAndMarathonNotesMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_TermLoansUnderCreditAgreementMember" name="TermLoansUnderCreditAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="zvra_TwoThousandFourteenEquityIncentivePlanMember" name="TwoThousandFourteenEquityIncentivePlanMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_UnderwritingAgreementAndOverallotmentOptionMember" name="UnderwritingAgreementAndOverallotmentOptionMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
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  <xsd:element id="zvra_UpfrontPayment" name="UpfrontPayment" nillable="true" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType" xbrli:balance="credit" xbrli:periodType="duration"/>
  <xsd:element id="zvra_VwapConsecutiveTradingDays" name="VwapConsecutiveTradingDays" nillable="true" substitutionGroup="xbrli:item" type="xbrli:durationItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_WarrantsMember" name="WarrantsMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element id="zvra_WarrantsPolicyTextBlock" name="WarrantsPolicyTextBlock" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_WarrantsToPurchaseCommonStockMember" name="WarrantsToPurchaseCommonStockMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_WellsFargoBankNaMember" name="WellsFargoBankNaMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_WorldwideExcludingEuropeMember" name="WorldwideExcludingEuropeMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_XomaLicenseAgreementMember" name="XomaLicenseAgreementMember" nillable="true" substitutionGroup="xbrli:item" type="dtr-types:domainItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="zvra_statement-statement-note-g-property-and-equipment-estimated-useful-lives-of-property-and-equipment-details" name="statement-statement-note-g-property-and-equipment-estimated-useful-lives-of-property-and-equipment-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="zvra_statement-statement-note-i-debt-obligations-aggregate-principal-amount-details" name="statement-statement-note-i-debt-obligations-aggregate-principal-amount-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-i-debt-obligations-future-minimum-principal-payments-details" name="statement-statement-note-i-debt-obligations-future-minimum-principal-payments-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-i-debt-obligations-tables" name="statement-statement-note-i-debt-obligations-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-l-stock-and-warrants-common-stock-activity-details" name="statement-statement-note-l-stock-and-warrants-common-stock-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-l-stock-and-warrants-reserved-authorized-shares-of-common-stock-for-future-issuance-details" name="statement-statement-note-l-stock-and-warrants-reserved-authorized-shares-of-common-stock-for-future-issuance-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
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  <xsd:element abstract="true" id="zvra_statement-statement-note-m-stockbased-compensation-blackscholes-optionpricing-model-details" name="statement-statement-note-m-stockbased-compensation-blackscholes-optionpricing-model-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-m-stockbased-compensation-information-regarding-currently-outstanding-and-exercisable-options-details" name="statement-statement-note-m-stockbased-compensation-information-regarding-currently-outstanding-and-exercisable-options-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-m-stockbased-compensation-nonvested-stock-option-awards-details" name="statement-statement-note-m-stockbased-compensation-nonvested-stock-option-awards-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-m-stockbased-compensation-restricted-stock-unit-activity-details" name="statement-statement-note-m-stockbased-compensation-restricted-stock-unit-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-m-stockbased-compensation-schedule-of-stock-option-activity-details" name="statement-statement-note-m-stockbased-compensation-schedule-of-stock-option-activity-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-m-stockbased-compensation-stockbased-compensation-expense-details" name="statement-statement-note-m-stockbased-compensation-stockbased-compensation-expense-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-m-stockbased-compensation-tables" name="statement-statement-note-m-stockbased-compensation-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-n-fair-value-of-financial-instruments-assets-and-liabilities-measured-at-fair-value-on-recurring-basis-details" name="statement-statement-note-n-fair-value-of-financial-instruments-assets-and-liabilities-measured-at-fair-value-on-recurring-basis-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-n-fair-value-of-financial-instruments-fair-value-assumptions-for-warrant-liabilities-details" name="statement-statement-note-n-fair-value-of-financial-instruments-fair-value-assumptions-for-warrant-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-n-fair-value-of-financial-instruments-reconciliation-of-beginning-and-ending-balances-for-derivative-and-warrant-liability-measured-at-fair-value-on-recurring-basis-details" name="statement-statement-note-n-fair-value-of-financial-instruments-reconciliation-of-beginning-and-ending-balances-for-derivative-and-warrant-liability-measured-at-fair-value-on-recurring-basis-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-n-fair-value-of-financial-instruments-tables" name="statement-statement-note-n-fair-value-of-financial-instruments-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-o-income-taxes-components-of-net-deferred-tax-assets-and-liabilities-details" name="statement-statement-note-o-income-taxes-components-of-net-deferred-tax-assets-and-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-o-income-taxes-schedule-of-reconciliation-of-difference-between-benefit-for-income-taxes-and-income-taxes-at-statutory-us-federal-income-tax-rate-details" name="statement-statement-note-o-income-taxes-schedule-of-reconciliation-of-difference-between-benefit-for-income-taxes-and-income-taxes-at-statutory-us-federal-income-tax-rate-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-o-income-taxes-tables" name="statement-statement-note-o-income-taxes-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-p-net-loss-per-share-antidilutive-securities-details" name="statement-statement-note-p-net-loss-per-share-antidilutive-securities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-p-net-loss-per-share-earnings-per-share-details" name="statement-statement-note-p-net-loss-per-share-earnings-per-share-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-p-net-loss-per-share-tables" name="statement-statement-note-p-net-loss-per-share-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-q-leases-lease-cost-details" name="statement-statement-note-q-leases-lease-cost-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-q-leases-maturities-of-lease-liabilities-details" name="statement-statement-note-q-leases-maturities-of-lease-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-q-leases-supplement-balance-sheet-information-related-to-lease-details" name="statement-statement-note-q-leases-supplement-balance-sheet-information-related-to-lease-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-q-leases-supplement-balance-sheet-information-related-to-lease-details-parentheticals" name="statement-statement-note-q-leases-supplement-balance-sheet-information-related-to-lease-details-parentheticals" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-q-leases-supplement-cash-flow-information-related-to-leases-details" name="statement-statement-note-q-leases-supplement-cash-flow-information-related-to-leases-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-q-leases-tables" name="statement-statement-note-q-leases-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-s-goodwill-intangible-assets-amortization-of-intangible-assets-details" name="statement-statement-note-s-goodwill-intangible-assets-amortization-of-intangible-assets-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-s-goodwill-intangible-assets-tables" name="statement-statement-note-s-goodwill-intangible-assets-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-t-merger-estimates-and-assumptions-related-to-fair-value-of-assets-and-liabilities-acquired-details" name="statement-statement-note-t-merger-estimates-and-assumptions-related-to-fair-value-of-assets-and-liabilities-acquired-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-t-merger-reconciliation-of-contingent-consideration-liabilities-details" name="statement-statement-note-t-merger-reconciliation-of-contingent-consideration-liabilities-details" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-note-t-merger-tables" name="statement-statement-note-t-merger-tables" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
  <xsd:element abstract="true" id="zvra_statement-statement-significant-accounting-policies-policies" name="statement-statement-significant-accounting-policies-policies" nillable="true" substitutionGroup="xbrli:item" type="xbrli:stringItemType" xbrli:periodType="duration"/>
</xsd:schema>
